Chondromyxoid fibroma cmf is a rarely encountered benign bone chondroid tumor. It occurs most frequently in the metaphysis of long tubular bones, and an epiphyseal location is exceedingly rare. Chondromyxoid fibroma is a benign tumor composed of spindle or stellate cells forming lobules. Metaphysis of long bones is the most common location of this tumor. Chondroblastoma differential diagnoses medscape reference. The histopathology result confirmed the diagnosis of chondromyxoid fibroma. The most helpful diagnostic feature is the nodular architecture of myxoid. Differential diagnosis of cartilaginous lesions of bone archives of.
A wide subtotal resection of the sternum and reconstruction with a. It accounts for less than 1 percent of all bone tumors and approximately 95 percent of these cases are seen in metaphysis of long bone. The primary pitfall in the histopathologic diagnosis of cmf. A 30yearold man with a 7month history of mild sacral pain and intermittant left sciatica was found to have an expansile lesion in the sacrum on a plain radiograph. On mri, surrounding minimal bone marrow oedema may be seen. The histology was composed of characteristic lobular features of this tumor with abundant cartilaginous matrix. We report a case of a 35yearold female with a 3 month history of lower back pain after sustaining a fall on her sacrumcoccyx presenting with a progressive complaint of localized lower back pain, occasional urinary retention without incontinence, gluteal hypesthesia, and. They are so close in histology that often radiology helps to make the final diagnosis.
It is composed of a mixture of chondroid, myxoid, and fibrous tissues. Acta orthop sand 57,375377,1986 chondromyxoid fibroma of the foot a report of a missed diagnosis james r. We report the second case of chondromyxoid fibroma cmf of the sternum, documented in the literature. It is associated with high local recurrence rates with a small risk chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. Chondromyxoid fibroma is a rare benign primary bone tumor of cartilage. Background chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up chondromyxoid fibroma cmf is a rare, slowgrowing, benign bone tumor of chondroblastic derivation. In this case, only histology of the biopsy was useful in diagnosing cmf before definitive surgery. The tumor has a lobular growth pattern with lobules of varying sizes as seen in this image. Definition and pathogenesis 1st described by jaffe and lichtenstein in 1948 previously classified as myxoma of bone bloodgood1924 or myxomatous variant of gct arises from the cartilageforming connective tissue of the marrow aberrations of 6q within t. Chondromyxoid fibroma cmf is an unusual bone tumor first. However, there a few case reports of this tumor arising from epiphysis of short tubular bones of the hand and feet. The diagnosis of cmf depends upon its characteristic histological appearance like a lobular pattern with stellateshaped cells in a myxoid or. The ultrastructural study exhibited stellate, ovoid or elongated tumor cells with features of cartilage cells and abundant loose matrix with many fine filamentous structures. Fineneedle aspiration biopsy of chondromyxoid fibroma.
A chondroblastoma is a rare, usually benign, tumor of bone that accounts for approximately 1% of all bone tumors. Chondromyxoid fibroma is often misdiagnosed being a radiological and pathological mimicker. Epidemiology imaging histopathology course and staging treatment. Chondromyxoid fibroma cmf is a rare, benign and potentially. Chondromyxoid fibroma of the maxillofacial region is typically seen in patients. Chondromyxoid fibroma cmf is a relatively uncommon benign bone tumor of cartilaginous differentiation. Chondromyxofibroma cmf is exceedingly rare, accounting. Chondromyxoid fibromas cmfs are extremely rare, benign cartilaginous neoplasms that account for chondromyxoid fibroma. Plain film radiograph shows lytic, oval, bubbly lesion with sclerotic rims. In this paper, we present a case of femoral chondromyxoid fibroma and discuss the rational reason for high accumulation of 18ffdg by petct in accordance with histology.
However, the case presented here is an extremely rare case as the tumor affected the middle and upper segment of the humerus. A rare case of juxtacortic chondromyxoid fibroma in. Chondromyxoid fibroma cmf is a rare, benign bone tumour. Chondroblastoma, a destructive lesion with a thin radiodense border, is usually seen in the epiphysis of long bones. Chondromyxoid fibroma is a type of cartilaginous tumor most cases are characterised by grm1 gene fusion or promoter swapping. In 1948, the tumor was first described by jaffe and lichtenstein as a lesion derived from cartilageforming tissue and composed of various proportions of chondroid, fibrous, and myxoid tissues.
Chondromyxoid fibroma at an unusual site srevatsa k, kangle rp. Jaffe and lichtenstein first described the condition in 1943. Occasional osteoclastlike giant multinucleated cells are encountered. Research open access chondromyxoid fibroma management. An 11yearold girl presented to our opd with complaints. Chondromyxoid fibroma like osteosarcoma cmfos is an exceedingly rare subtype of lowgrade. A rare case of epiphyseal chondromyxoid fibroma of the. Chondromyxoid fibroma of the sacrum and left iliac bone. Chondromyxoid fibroma cmf is a benign neoplasm accounting for fewer than 1% of all bone tumors. Files are available under licenses specified on their description page. Chondromyxoid fibroma is an uncommon benign cartilaginous tumor of the bone.
Cementoossifying fibroma was initially classified by the world health organization who as a fibroosseous neoplasm. Typical radiographic features include bubbly lucency and sclerotic rim located eccentrically within the metaphysis of long bones commonly the tibia. Chondromyxoid fibroma is a rare tumor which comprises less than 1% of all benign bone tumors, and it is the least common benign cartilaginous tumor of. Biopsy confirmed a chondromyxoid fibroma which was removed surgically. There are 76 cases of chondromyxoid fib roma in the file5 of the department of surgi cal pathology of the mayo clinic.
Well circumscribed, hypocellular lobules of poorly formed hyaline cartilage composed of chondroblasts with abundant pink cytoplasm and myxoid tissue with fibrous septae containing spindle cells and osteoclasts. The lobules have a hypocellular center with condensation of tumor cells at the periphery. Plain film and mri appearances, histology and treatment are described. Chondromyxoid fibroma cmf is a benign cartilage tumor that also has myxoid and fibrous elements. Frank, dds,d iowa city, iowa university of iowa chondromyxoid fibroma is a benign tumor of bone that is characterized by chondroid and. Case report open access chondromyxoid fibroma like osteosarcoma. Chondromyxoid fibroma cmf is a rare benign neoplasm of cartilaginous origin. Chondromyxoid fibroma cmf is one of the rarest of bone tumors, accounting for less than 1% of all bone tumors.
As the name suggests, chondromyxoid fibroma shows chondroid, myxomatous, and fibrous zones. Pdf chondromyxoid fibroma cmf is one of the rarest benign tumors of cartilaginous origin. The term chondromyxoid fibroma reflects the variety of tissues that characterize this lesion. Activating rearrangements of grm1 metabotropic glutamate receptor 1. Benign cartilage lesions can be divided into those that differentiate towards fetal type cartilage chondroblastoma and chondromyxoid fibroma and those that differentiate towards mature hyaline type cartilage osteochondroma, chondroma. Acknowledgment we thank barbara almarez mahinda for secretarial support. Hence, to explore the clinical manifestations, diagnostic tests, and therapeutic procedures for temporal bone cartilage myxoid fibroma, it is important to optimize patient treatment and avoid overtreatment. We present here an unusual case of a chondromyxoid fibroma that occurred in the epiphysis of the proximal tibia with an open growth plate. It has a predilection for men in the second and third decades of life with the metaphyseal regions of the long bones of the lower extremities as the favored sites of occurrence. Chondromyxoid fibroma cmf is a rare form of benign bone tumor and easily misdiagnosed as fibrosarcoma.
Chondromyxoid fibroma cmf is an extremely rare, benign cartilaginous tumor that makes up case description. All structured data from the file and property namespaces is available under the creative commons cc0 license. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings may mimic more. It is extremely rare and accounts for less that 1% of all bone tumors. Chondromyxoid fibroma cmf is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. In 1931, codman classified it as a chondromatous variant of giant cell tumors, when he described these lesions in the proximal humerus. A resected case of chondromyxoid fibroma of the right fibula in a 31.
This rare benign tumor has a striking predilection for the bones of the tibia and the foot. However, no paper has explained the reason for this high accumulation. Various treatment options are available for this tumour and recurrences have been reported following surgery. Chondromyxoid fibroma cmf was first described by jaffe and lichtenstein 1. Chondromyxoid fibroma of bone, pathology international. It is a benign noncancerous tumor that most often develops in older children and young adults under 30 years of age. The histological sections showed mitochondrion lobules with increased cellularity in the peripheral area. Lemmens a chondromyxoid fibroma in th calcaneus of an 11year old girl wa pri marily diagnosed as a solitary bone cyst. Chondromyxoid fibroma cmf is a rare entity, representing histology. Chondromyxoid fibroma cmf is a benign, locally aggressive tumor of cartilaginous origin and accounts for less than 0. Chondroblastoma and chondromyxoid fibroma abstract chondroblastoma and chondromyxoid. Chondromyxoid fibroma of the sacrum and left iliac bone ajr.
Cell biology and matrix biochemistry of chondromyxoid fibroma. Nora lesion is a reactive periostitis that mimics osteochondroma and is discussed with this group of lesions. Specimens from cases of chondromyxoid fibromas from the mayo bone tumor registry, rochester, mn, and the. Cementoossifying fibroma cof is a distinct form of a benign fibroosseous tumor, affecting predominantly the craniofacial region.
485 1183 1434 10 1556 782 976 1252 334 576 863 483 337 1192 1092 339 358 909 1316 1437 253 1368 832 1412 1377 83 1312 1460 291 759 298 1407 982 569 1117 816 306